Touch screens - the beginning of the end for the mouse.
I hope the iPad is the beginning of touch screen integration into all apple products. MacBooks and iMacs would be wonderful with an entire touch screen. No longer this disconnect between the pointing device and the thing you want to interact with, want to move a window, drag it, want to resize a window pinch it.
It could be the beginning of the end for the mouse. Not for everyone, specialist, such as graphic designers and possibly programmers would probably still need a mouse, if they don't like or know keyboard short cuts.
Here is hoping my next laptop is a MacBookPro with the optional touch screen interface.